DICER Polyclonal Antibody
Ucallm_WP3317-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010],
Specifications
| Size | 50μL/100μL |
| Target | DICER |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 211kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DICER Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | DICER1 DICER HERNA KIAA0928 |
| Protein Name | Endoribonuclease Dicer (Helicase with RNase motif) (Helicase MOI) |
| Other Name | |
| Species | Human |
| Gene ID | 23405 |
| Uniprot | Q9UPY3, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8R418 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cytoplasm, perinuclear region . |
| Tissue Expression | Brain,Lung,Testis, |
| Signaling_pathway | Human Diseases >> Cancer: overview >> MicroRNAs in cancer |
| Research Areas | >>MicroRNAs in cancer |
| Function | cofactor:Binds 2 magnesium or manganese ions per subunit.,Function:Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.,online information:The dark side of RNA -Issue 87 of October 2007,similarity:Belongs to the helicase family. Dicer subfamily.,similarity:Contains 1 Dicer dsRNA-binding fold domain.,similarity:Contains 1 DRBM (double-stranded RNA-binding) domain.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 PAZ domain.,similarity:Contains 2 RNase III domains.,subunit:Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, EIF2C1, PIWIL1 and PRKRA. Associates with the 60S ribosome., |
Please login to post questions
Related products
