Product details
Background:
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DNAJB9 rabbit pAb
Ucallm_WP6408-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | DNAJB9 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 25kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DNAJB9 |
| Specificity | This antibody detects endogenous levels of DNAJB9 at Human, Mouse,Rat |
| Gene Name | DNAJB9 MDG1 UNQ743/PRO1471 |
| Protein Name | DnaJ homolog subfamily B member 9 (Microvascular endothelial differentiation gene 1 protein) (Mdg-1) |
| Other Name | |
| Species | Human |
| Gene ID | 4189 |
| Uniprot | Q9UBS3, |
| Species.1 | Mouse |
| Gene ID.1 | 27362 |
| Uniprot.1 | Q9QYI6, |
| Species.2 | Rat |
| Gene ID.2 | 24908 |
| Uniprot.2 | P97554 |
| Cellular Localization | Endoplasmic reticulum lumen . |
| Tissue Expression | Widely expressed. Expressed at highest level in the liver, placenta and kidney (PubMed:11836248). |
| Signaling_pathway | |
| Research Areas | |
| Function | Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins . In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity). |
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