Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human DNASE2B
Specificity
This antibody detects endogenous levels of DNASE2B at Human, Mouse,Rat
Gene Name
DNASE2B DLAD
Protein Name
Deoxyribonuclease-2-beta (DNase II-like acid DNase) (DNase2-like acid DNase) (Deoxyribonuclease II beta) (DNase II beta) (Endonuclease DLAD)
Other Name
Species
Human
Gene ID
58511
Uniprot
Q8WZ79,
Species.1
Mouse
Gene ID.1
56629
Uniprot.1
Q9QY48,
Species.2
Rat
Gene ID.2
59296
Uniprot.2
Q9QZK9
Cellular Localization
Lysosome .
Tissue Expression
Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific.
Signaling_pathway
Cellular Processes >> Transport and catabolism >> Lysosome;Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway
Research Areas
Function
Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.