Name: DOCK 2 Polyclonal Antibody
SKU: WP12049
Price: 268 USD
Availability: InStock

DOCK 2 Polyclonal Antibody

Ucallm_WP12049-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP12049-100

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016],

Specifications

Size	50μL/100μL
Target	DOCK 2
Reactivity	Human, Mouse, Rat
Applications	IHC, IF, ELISA
MW(Calculated)	212kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from the Internal region of human DOCK 2.
Specificity	DOCK 2 Polyclonal Antibody detects endogenous levels of DOCK 2 protein.
Gene Name	DOCK2
Protein Name	Dedicator of cytokinesis protein 2
Other Name	DOCK2; / KIAA0209; / Dedicator of cytokinesis protein 2
Species	Human
Gene ID	1794
Uniprot	Q92608,
Species.1	Mouse
Gene ID.1	94176
Uniprot.1	Q8C3J5
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Endomembrane system; Peripheral membrane protein . Cytoplasm, cytoskeleton . Colocalizes with F-actin.
Tissue Expression	Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.
Signaling_pathway	Organismal Systems >> Immune system >> Chemokine signaling pathway
Research Areas	>>Chemokine signaling pathway
Function	Domain:The DHR-2 domain may mediate the GEF activity.,Function:Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2 small GTPases, probably by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.,similarity:Belongs to the DOCK family.,similarity:Contains 1 DHR-1 (CZH-1) domain.,similarity:Contains 1 DHR-2 (CZH-2) domain.,similarity:Contains 1 SH3 domain.,subcellular location:Colocalizes with F-actin.,subunit:Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z.,tissue specificity:Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.,