DPP6 Polyclonal Antibody
Ucallm_WP2649-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014],
Specifications
| Size | 50μL/100μL |
| Target | DPP6 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 95kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 750-830 |
| Specificity | DPP6 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | DPP6 |
| Protein Name | Dipeptidyl aminopeptidase-like protein 6 (DPPX) (Dipeptidyl aminopeptidase-related protein) (Dipeptidyl peptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl peptidase VI) (DPP VI) |
| Other Name | |
| Species | Human |
| Gene ID | 1804 |
| Uniprot | P42658, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9Z218, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P46101 |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein . |
| Tissue Expression | Expressed predominantly in brain. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Genetic variation in DPP6 may influence susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a severely disabling and lethal disorder caused by progressive degeneration of motor neurons in the brain, spinal cord and brainstem.,Function:May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity. May modulate the cell surface expression and the activity of the potassium channel KCND2.,similarity:Belongs to the peptidase S9B family.,subunit:Homodimer. Binds KCND2.,tissue specificity:Expressed predominantly in brain., |
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