Price range: $268.00 through $328.00
Background:
This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011],
| Size | 50μL/100μL |
| Target | DRS-1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PECI. AA range:73-122 |
| Specificity | DRS-1 Polyclonal Antibody detects endogenous levels of DRS-1 protein. |
| Gene Name | ECI2 |
| Protein Name | Enoyl-CoA delta isomerase 2 mitochondrial |
| Other Name | ECI2; / DRS1; / HCA88; / PECI; / Enoyl-CoA delta isomerase 2; / mitochondrial; / DRS-1; / Delta; / 3; / ,delta; / 2; / -enoyl-CoA isomerase; / D3,D2-enoyl-CoA isomerase; / Diazepam-binding inhibitor-related protein 1; / DBI-related protein 1; / Dodecenoyl-CoA isomerase; / Hep |
| Species | Human |
| Gene ID | 10455 |
| Uniprot | O75521, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9WUR2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Mitochondrion .; [Isoform 2]: Peroxisome matrix . |
| Tissue Expression | Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Peroxisome |
| Research Areas | >>Fatty acid degradation; / >>Peroxisome |
| Function | Catalytic activity:(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.,Function:Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.,similarity:Contains 1 ACB (acyl-CoA-binding) domain.,similarity:In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.,tissue specificity:Abundant in heart, skeletal muscle and liver., |
