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Background:The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. A pseudogene has been identified on chromosome 12. [provided by RefSeq, May 2010],
| Target | NDUFA9 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 43kD |
| MW(Observed) | 36kD |
| Host Species | Mouse |
| Isotype | Mouse IgG1/Kappa |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | IHC 1:100-1:200; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Source | |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | PTR1441 |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Sequence | |
| Specificity | Endogenous |
| Gene Name | NDUFA9 |
| Protein Name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 mitochondrial |
| Other Name | NDUFA9; / NDUFS2L; / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9; / mitochondrial; / Complex I-39kD; / CI-39kD; / NADH-ubiquinone oxidoreductase 39 kDa subunit |
| Species | Human |
| Gene ID-1 | 4704 |
| Uniprot | Q16795, |
| Species.1 | Mouse |
| Gene ID-2 | 66108 |
| Uniprot.1 | Q9DC69, |
| Species.2 | Rat |
| Gene ID-3 | 362440 |
| Uniprot.2 | Q5BK63 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. A pseudogene has been identified on chromosome 12. [provided by RefSeq, May 2010], |
| Cellular Localization | Mitochondrion matrix . |
| Tissue Expression | Blood,Colon,Liver,Muscle,Placenta,Skeletal muscle, |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Oxidative phosphorylation; / >>Metabolic pathways; / >>Thermogenesis; / >>Retrograde endocannabinoid signaling; / >>Non-alcoholic fatty liver disease; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Chemical carcinogenesis - reactive oxygen species; / >>Diabetic cardiomyopathy |
| Function | cofactor:Binds 1 FAD per subunit.,Function:Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.,similarity:Belongs to the complex I NDUFA9 subunit family.,subunit:Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction., |
| RRID |
