DUS2L Polyclonal Antibody
Ucallm_WP12076-50
Price range: $268.00 through $328.00
Product details
Background:
dihydrouridine synthase 2(DUS2) Homo sapiens This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012],
Specifications
| Size | 50μL/100μL |
| Target | DUS2L |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DUS2L. AA range:421-470 |
| Specificity | DUS2L Polyclonal Antibody detects endogenous levels of DUS2L protein. |
| Gene Name | DUS2L |
| Protein Name | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like |
| Other Name | DUS2L; / DUS2; / tRNA-dihydrouridine; / 20; / synthase [NAD; / P; / +]-like; / Up-regulated in lung cancer protein 8; / URLC8; / tRNA-dihydrouridine synthase 2-like; / hDUS2 |
| Species | Human |
| Gene ID | 54920 |
| Uniprot | Q9NX74, |
| Species.1 | Mouse |
| Gene ID.1 | 66369 |
| Uniprot.1 | Q9D7B1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Endoplasmic reticulum . Mainly at the endoplasmic reticulum. . |
| Tissue Expression | Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | cofactor:FAD.,Function:Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.,similarity:Belongs to the dus family. Dus2 subfamily.,similarity:Contains 1 DRBM (double-stranded RNA-binding) domain.,subcellular location:Mainly at the endoplasmic reticulum.,subunit:Interacts with EPRS.,tissue specificity:Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level)., |
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