Price range: $268.00 through $328.00
Background:
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012],
| Size | 50μL/100μL |
| Target | E-Ras |
| Reactivity | Human, Mouse |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 25kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ERAS. AA range:184-233 |
| Specificity | E-Ras Polyclonal Antibody detects endogenous levels of E-Ras protein. |
| Gene Name | ERAS |
| Protein Name | GTPase Eras |
| Other Name | ERAS; / HRAS2; / HRASP; / GTPase ERas; / E-Ras; / Embryonic stem cell-expressed Ras |
| Species | Human |
| Gene ID | 3266 |
| Uniprot | Q7Z444, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q7TN89 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Lipid-anchor; Cytoplasmic side . |
| Tissue Expression | Brain, |
| Signaling_pathway | |
| Research Areas | |
| Function | enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).,Function:Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.,similarity:Belongs to the small GTPase superfamily. Ras family.,subunit:Interacts with PIK3CD., |
