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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/EDG-4 Polyclonal Antibody
SKU: WP12114 Categories: ,

EDG-4 Polyclonal Antibody

Ucallm_WP12114-50

Price range: $268.00 through $328.00

SKU: WP12114-100
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Product details

Background:

lysophosphatidic acid receptor 2(LPAR2) Homo sapiens This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetEDG-4
ReactivityHuman, Mouse, Monkey
ApplicationsWB, IF, ELISA
MW(Calculated)
MW(Observed)39kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human EDG4. AA range:271-320
SpecificityEDG-4 Polyclonal Antibody detects endogenous levels of EDG-4 protein.
Gene NameLPAR2
Protein NameLysophosphatidic acid receptor 2
Other NameLPAR2; / EDG4; / LPA2; / Lysophosphatidic acid receptor 2; / LPA receptor 2; / LPA-2; / Lysophosphatidic acid receptor Edg-4
SpeciesHuman
Gene ID9170
UniprotQ9HBW0,
Species.1Mouse
Gene ID.1
Uniprot.1Q9JL06
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell surface . Cell membrane; Multi-pass membrane protein . Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
Tissue ExpressionExpressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.
Signaling_pathwayCellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas>>Rap1 signaling pathway; / >>Phospholipase D signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>PI3K-Akt signaling pathway; / >>Regulation of actin cytoskeleton; / >>Pathogenic Escherichia coli infection; / >>Pathways in cancer
FunctionFunction:Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway.,miscellaneous:PubMed:9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells that formed a tumor.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3.,tissue specificity:Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.,
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