EDG-5 Polyclonal Antibody
Ucallm_WP12115-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016],
Specifications
| Size | 50μL/100μL |
| Target | EDG-5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 39kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EDG5. AA range:261-310 |
| Specificity | EDG-5 Polyclonal Antibody detects endogenous levels of EDG-5 protein. |
| Gene Name | S1PR2 |
| Protein Name | Sphingosine 1-phosphate receptor 2 |
| Other Name | S1PR2; / EDG5; / Sphingosine 1-phosphate receptor 2; / S1P receptor 2; / S1P2; / Endothelial differentiation G-protein coupled receptor 5; / Sphingosine 1-phosphate receptor Edg-5; / S1P receptor Edg-5 |
| Species | Human |
| Gene ID | 9294 |
| Uniprot | O95136, |
| Species.1 | Mouse |
| Gene ID.1 | 14739 |
| Uniprot.1 | P52592, |
| Species.2 | Rat |
| Gene ID.2 | 29415 |
| Uniprot.2 | P47752 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Fetal brain, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway |
| Research Areas | >>Sphingolipid signaling pathway; / >>Neuroactive ligand-receptor interaction |
| Function | Function:Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.,similarity:Belongs to the G-protein coupled receptor 1 family., |
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