Product details
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EIF2S3 rabbit pAb
Ucallm_WP7028-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | EIF2S3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 52kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human EIF2S3 |
| Specificity | This antibody detects endogenous levels of EIF2S3 at Human, Mouse,Rat |
| Gene Name | EIF2S3 EIF2G |
| Protein Name | Eukaryotic translation initiation factor 2 subunit 3 (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF-2-gamma X) (eIF-2gX) |
| Other Name | |
| Species | Human |
| Gene ID | 1968 |
| Uniprot | P41091, |
| Species.1 | Mouse |
| Gene ID.1 | 26905 |
| Uniprot.1 | Q9Z0N1, |
| Species.2 | Rat |
| Gene ID.2 | 100312984 |
| Uniprot.2 | P81795 |
| Cellular Localization | |
| Tissue Expression | Expressed in testis, brain, liver and muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). |
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