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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/EIF4EBP3 mouse mAb
SKU: WM0737 Categories: ,

EIF4EBP3 mouse mAb

Ucallm_WM0737-50

Price range: $268.00 through $328.00

SKU: WM0737-50
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Product details

Background:
eukaryotic translation initiation factor 4E binding protein 3(EIF4EBP3) Homo sapiens This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010],

Specifications

Size50μL/100μL
TargetEIF4EBP3
ReactivityTransfected
ApplicationsWB
MW(Calculated)
MW(Observed)11kD
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:1000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number14A6
ImmunogenRecombinant protein of human EIF4EBP3.
SpecificityTransfected Only.
Gene Nameeif4ebp3
Protein Name
Other Name4E BP3; / 4E-BP3; / 4EBP3; / eIF4E binding protein 3; / Eukaryotic initiation factor 4E binding protein 3; / Eukaryotic translation initiation factor 4E binding protein 3; / OTTHUMP00000159879.
SpeciesHuman
Gene ID8637
UniprotO60516,
Species.1Mouse
Gene ID.1
Uniprot.1Q80VV3
Species.2
Gene ID.2
Uniprot.2
Cellular Localizationcytoplasm,membrane,eukaryotic translation initiation factor 4F complex,
Tissue ExpressionExpression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.
Signaling_pathway
Research Areas
FunctionFunction:May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.,Function:Regulates eIF4E activity by preventing its assembly into the eIF4F complex.,PTM:Phosphorylated.,similarity:Belongs to the eIF4E-binding protein family.,similarity:Belongs to the mask family.,similarity:Contains 1 KH domain.,similarity:Contains 25 ANK repeats.,subunit:EIF4EBP3 interacts with EIF4E.,subunit:Interacts with PTPN11. Isoform 2 interacts with VPR.,tissue specificity:Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.,tissue specificity:Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expression in leukemia cells. Isoform 2 is highly expressed in spleen with almost no expression in muscle and brain.,
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