EMAL4 rabbit pAb
Ucallm_WP17020-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015],
Specifications
| Size | 50μL/100μL |
| Target | EMAL4 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 108kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human EMAL4 AA range: 398-448 |
| Specificity | This antibody detects endogenous levels of EMAL4 at Human/Mouse |
| Gene Name | EML4 C2orf2 EMAPL4 |
| Protein Name | EMAL4 |
| Other Name | |
| Species | Human |
| Gene ID | 27436 |
| Uniprot | Q9HC35, |
| Species.1 | Mouse |
| Gene ID.1 | 78798 |
| Uniprot.1 | Q3UMY5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center . Midbody . Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis. . |
| Tissue Expression | |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Human Diseases >> Cancer: specific types >> Non-small cell lung cancer |
| Research Areas | >>Pathways in cancer; / >>Non-small cell lung cancer; / >>PD-L1 expression and PD-1 checkpoint pathway in cancer |
| Function | developmental stage:Strongly overexpressed during mitosis.,Function:May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.,similarity:Belongs to the WD repeat EMAP family.,similarity:Contains 9 WD repeats., |
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