Price range: $268.00 through $328.00
Background:
This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009],
| Size | 50μL/100μL |
| Target | PTGER2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PE2R2. AA range:261-310 |
| Specificity | EP2 Polyclonal Antibody detects endogenous levels of EP2 protein. |
| Gene Name | PTGER2 |
| Protein Name | Prostaglandin E2 receptor EP2 subtype |
| Other Name | PTGER2; / Prostaglandin E2 receptor EP2 subtype; / PGE receptor EP2 subtype; / PGE2 receptor EP2 subtype; / Prostanoid EP2 receptor |
| Species | Human |
| Gene ID | 5732 |
| Uniprot | P43116, |
| Species.1 | Mouse |
| Gene ID.1 | 19217 |
| Uniprot.1 | Q62053, |
| Species.2 | Rat |
| Gene ID.2 | 81752 |
| Uniprot.2 | Q62928 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Placenta and lung. |
| Signaling_pathway | Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Inflammatory mediator regulation of TRP channels; / >>Renin secretion; / >>Human cytomegalovirus infection; / >>Pathways in cancer |
| Function | Function:Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Placenta and lung., |
