EphA4 Monoclonal Antibody
Ucallm_WM0162-50
Price range: $268.00 through $328.00
Product details
Background:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],
Specifications
| Size | 50μL/100μL |
| Target | EphA4 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 110kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 20B3 |
| Immunogen | Purified recombinant fragment of EphA4 (aa777-986) expressed in E. Coli. |
| Specificity | EphA4 Monoclonal Antibody detects endogenous levels of EphA4 protein. |
| Gene Name | EPHA4 |
| Protein Name | Ephrin type-A receptor 4 |
| Other Name | EPHA4; / HEK8; / SEK; / TYRO1; / Ephrin type-A receptor 4; / EPH-like kinase 8; / EK8; / hEK8; / Tyrosine-protein kinase TYRO1; / Tyrosine-protein kinase receptor SEK |
| Species | Human |
| Gene ID | 2043 |
| Uniprot | P54764, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q03137 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, postsynaptic density membrane . Early endosome . Cell junction, adherens junction . Clustered upon activation and targeted to early endosome. . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | >>Axon guidance |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Domain:The protein kinase domain mediates interaction with NGEF/ephexin-1.,Function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with the src family kinase, p59-Fyn, through the major phosphorylation site at position Tyr-602. Interacts with NGEF/ephexin-1.,tissue specificity:Ubiquitous., |
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