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Ephrin-A1 Polyclonal Antibody
Ucallm_WP12214-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Ephrin-A1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 24kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EFNA1. AA range:66-115 |
| Specificity | Ephrin-A1 Polyclonal Antibody detects endogenous levels of Ephrin-A1 protein. |
| Gene Name | EFNA1 EPLG1 LERK1 TNFAIP4 |
| Protein Name | Ephrin-A1 |
| Other Name | EFNA1; / EPLG1; / LERK1; / TNFAIP4; / Ephrin-A1; / EPH-related receptor tyrosine kinase ligand 1; / LERK-1; / Immediate early response protein B61; / Tumor necrosis factor alpha-induced protein 4; / TNF alpha-induced protein 4; / [Cleaved into: Ephrin-A1, secreted form] |
| Species | Human |
| Gene ID | 1942 |
| Uniprot | P20827, |
| Species.1 | Mouse |
| Gene ID.1 | 13636 |
| Uniprot.1 | P52793, |
| Species.2 | Rat |
| Gene ID.2 | 94268 |
| Uniprot.2 | P97553 |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor .; [Ephrin-A1, secreted form]: Secreted . |
| Tissue Expression | Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). |
| Signaling_pathway | Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>PI3K-Akt signaling pathway; / >>Axon guidance; / >>MicroRNAs in cancer |
| Function | induction:By TNF-alpha and interleukin-1 beta.,similarity:Belongs to the ephrin family.,subunit:Binds to the receptor tyrosine kinases EPHA2, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1., |
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