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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/ERp57 Polyclonal Antibody
SKU: WP15294 Categories: ,

ERp57 Polyclonal Antibody

Ucallm_WP15294-50

Price range: $268.00 through $328.00

SKU: WP15294-100
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Product details

Background:

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetERp57
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)55kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PDIA3. AA range:111-160
SpecificityERp57 Polyclonal Antibody detects endogenous levels of ERp57 protein.
Gene NamePDIA3
Protein NameProtein disulfide-isomerase A3
Other NamePDIA3; / ERP57; / ERP60; / GRP58; / Protein disulfide-isomerase A3; / 58 kDa glucose-regulated protein; / 58 kDa microsomal protein; / p58; / Disulfide isomerase ER-60; / Endoplasmic reticulum resident protein 57; / ER protein 57; / ERp57; / Endoplasmic reticulum resident protein 60; / ER protein 60; / ERp60
SpeciesHuman
Gene ID2923
UniprotP30101,
Species.1Mouse
Gene ID.114827
Uniprot.1P27773,
Species.2Rat
Gene ID.229468
Uniprot.2P11598
Cellular LocalizationEndoplasmic reticulum . Endoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). .
Tissue ExpressionDetected in the flagellum and head region of spermatozoa (at protein level) (PubMed:20400973). Expressed in liver, stomach and colon (at protein level). Expressed in gastric parietal cells and chief cells (at protein level) (PubMed:24188822).
Signaling_pathwayOrganismal Systems >> Immune system >> Antigen processing and presentation;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum
Research Areas>>Protein processing in endoplasmic reticulum; / >>Antigen processing and presentation; / >>Human cytomegalovirus infection; / >>Herpes simplex virus 1 infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection
FunctionCatalytic activity:Catalyzes the rearrangement of -S-S- bonds in proteins.,Caution:Was originally thought to be a phosphatidylinositol-4,5-bisphosphate phosphodiesterase type I (phospholipase C-alpha).,mass spectrometry: PubMed:11840567,similarity:Belongs to the protein disulfide isomerase family.,similarity:Contains 2 thioredoxin domains.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with ERP27 and CANX.,
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