Price range: $268.00 through $328.00
Background:
Mutations in this gene have been shown to cause an X-linked dominant STAR syndrome that typically manifests syndactyly, telecanthus and anogenital and renal malformations. The protein encoded by this gene contains a cyclin-box-fold domain which suggests it may have a role in controlling nuclear cell division cycles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],
| Size | 50μL/100μL |
| Target | FA58A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 27kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 30-110 |
| Specificity | FA58A Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | FAM58A |
| Protein Name | Cyclin-related protein FAM58A (Cyclin-M) |
| Other Name | |
| Species | Human |
| Gene ID | 92002 |
| Uniprot | Q8N1B3, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8QZR8, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q4QQW5 |
| Cellular Localization | cyclin-dependent protein kinase holoenzyme complex,nucleus, |
| Tissue Expression | B-cell,Blood,Kidney,Lung, |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in FAM58A are the cause of toe syndactyly, telecanthus, and anogenital and renal malformations (STAR) [MIM:300707]; also known as STAR syndrome or syndactyly with renal and anogenital malformations.,Function:May have a role in cell proliferation.,similarity:Belongs to the cyclin family. Cyclin-like FAM58 subfamily.,subunit:Interacts with SALL1., |
