Product details
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FAM175A rabbit pAb
Ucallm_WP8888-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ABRAXAS1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 45kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FAM175A |
| Specificity | This antibody detects endogenous levels of FAM175A at Human, Mouse,Rat |
| Gene Name | FAM175A ABRA1 CCDC98 UNQ496/PRO1013 |
| Protein Name | BRCA1-A complex subunit Abraxas (Coiled-coil domain-containing protein 98) (Protein FAM175A) |
| Other Name | |
| Species | Human |
| Gene ID | 84142 |
| Uniprot | Q6UWZ7, |
| Species.1 | Mouse |
| Gene ID.1 | 70681 |
| Uniprot.1 | Q8BPZ8, |
| Species.2 | Rat |
| Gene ID.2 | 289468 |
| Uniprot.2 | Q5I0F1 |
| Cellular Localization | Nucleus . Localizes at sites of DNA damage at double-strand breaks (DSBs). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
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