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FBXO5 rabbit pAb
Ucallm_WP6550-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | FBXO5 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 49kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FBXO5 |
| Specificity | This antibody detects endogenous levels of FBXO5 at Human, Mouse |
| Gene Name | FBXO5 EMI1 FBX5 |
| Protein Name | F-box only protein 5 (Early mitotic inhibitor 1) |
| Other Name | |
| Species | Human |
| Gene ID | 26271 |
| Uniprot | Q9UKT4, |
| Species.1 | Mouse |
| Gene ID.1 | 67141 |
| Uniprot.1 | Q7TSG3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, spindle . In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration (PubMed:11988738). In mitotic cells, localizes throughout the cell, particularly at the spindle (PubMed:15469984). . |
| Tissue Expression | |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Cell cycle |
| Research Areas | |
| Function | Regulator of APC activity during mitotic and meiotic cell cycle . During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex . During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase . Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment . As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities . Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence . During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity). Promotes migration and osteogenic differentiation of mesenchymal stem cells . |
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