Product details
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FCHO1 rabbit pAb
Ucallm_WP7852-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | FCHO1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 98kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FCHO1 |
| Specificity | This antibody detects endogenous levels of FCHO1 at Human, Mouse |
| Gene Name | FCHO1 KIAA0290 |
| Protein Name | FCH domain only protein 1 |
| Other Name | |
| Species | Human |
| Gene ID | 23149 |
| Uniprot | O14526, |
| Species.1 | Mouse |
| Gene ID.1 | 74015 |
| Uniprot.1 | Q8K285 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side . Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes. |
| Tissue Expression | Predominantly expressed in lymphoid cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Functions in an early step of clathrin-mediated endocytosis . Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation . Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation . |
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