SKU: WP2424 Categories: ,

FCN2 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2424-100
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Product details

Background:

ficolin 2(FCN2) Homo sapiens The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetFCN2
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)34kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein AA range: 41-90
SpecificityFCN2 Polyclonal Antibody detects endogenous levels of protein.
Gene NameFCN2 FCNL
Protein NameFicolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35)
Other Name
SpeciesHuman
Gene ID2220
UniprotQ15485,
Species.1Mouse
Gene ID.1
Uniprot.1O70497,
Species.2Rat
Gene ID.2
Uniprot.2P57756
Cellular LocalizationSecreted.
Tissue ExpressionExpressed by the liver and secreted in plasma.
Signaling_pathway
Research Areas
FunctionDomain:The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydrate binding.,Function:May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.,similarity:Belongs to the ficolin lectin family.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 fibrinogen C-terminal domain.,subunit:Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2.,tissue specificity:Expressed by the liver and secreted in plasma.,
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