Price range: $268.00 through $328.00
Background:
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011],
| Size | 50μL/100μL |
| Target | FLVC1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 61kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 481-530 |
| Specificity | FLVC1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | FLVCR1 FLVCR |
| Protein Name | Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (hFLVCR) |
| Other Name | |
| Species | Human |
| Gene ID | 28982 |
| Uniprot | Q9Y5Y0 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Cell membrane; Multi-pass membrane protein .; [Isoform 2]: Mitochondrion membrane; Multi-pass membrane protein . |
| Tissue Expression | Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | developmental stage:Down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization. Abundant in fetal liver.,Function:Exports cytoplasmic heme. May be required to protect developing erythroid cells from heme toxicity. Causes susceptibility to FeLV-C in vitro.,similarity:Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.,tissue specificity:Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney., |
