The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011],
Specifications
Size
50μL/100μL
Target
FMT
Reactivity
Human, Mouse, Rat
Applications
WB
MW(Calculated)
43kD
MW(Observed)
Host Species
Rabbit
Isotype
IgG
Conjugate/Modification
Unmodified
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human FMT AA range: 115-165
Specificity
This antibody detects endogenous levels of FMT at Human/Mouse/Rat
Gene Name
MTFMT FMT FMT1
Protein Name
FMT
Other Name
Species
Human
Gene ID
123263
Uniprot
Q96DP5,
Species.1
Mouse
Gene ID.1
69606
Uniprot.1
Q9D799,
Species.2
Rat
Gene ID.2
315763
Uniprot.2
Q5I0C5
Cellular Localization
Mitochondrion .
Tissue Expression
Signaling_pathway
Research Areas
>>One carbon pool by folate; / >>Aminoacyl-tRNA biosynthesis; / >>Metabolic pathways
Function
Catalytic activity:10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) + H(2)O = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).,Domain:Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C-terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction.,Function:Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism.,similarity:Belongs to the fmt family.,