SKU: WM0200 Categories: ,

FoxA2 Monoclonal Antibody

Price range: $268.00 through $328.00

SKU: WM0200-50
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Product details

Background:
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008],

Specifications

Size50μL/100μL
TargetFoxA2
ReactivityHuman
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)48kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationAffinity purification
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number15H1
ImmunogenPurified recombinant fragment of FoxA2 expressed in E. Coli.
SpecificityFoxA2 Monoclonal Antibody detects endogenous levels of FoxA2 protein.
Gene NameFOXA2
Protein NameHepatocyte nuclear factor 3-beta
Other NameFOXA2; / HNF3B; / TCF3B; / Hepatocyte nuclear factor 3-beta; / HNF-3-beta; / HNF-3B; / Forkhead box protein A2; / Transcription factor 3B; / TCF-3B
SpeciesHuman
Gene ID3170
UniprotQ9Y261,
Species.1Mouse
Gene ID.1
Uniprot.1P35583
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus . Cytoplasm . Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
Tissue ExpressionLiver,Lung,
Signaling_pathwayOrganismal Systems >> Aging >> Longevity regulating pathway - multiple species
Research Areas>>Longevity regulating pathway - multiple species; / >>Maturity onset diabetes of the young
FunctionFunction:Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes.,online information:Hepatocyte nuclear factors entry,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Binds TLE1.,
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