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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/FSHβ Polyclonal Antibody
SKU: WP15847 Categories: ,

FSHβ Polyclonal Antibody

Ucallm_WP15847-50

Price range: $268.00 through $328.00

SKU: WP15847-100
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Product details

Background:

follicle stimulating hormone beta subunit(FSHB) Homo sapiens The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetFSH
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF, ELISA
MW(Calculated)
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthetic peptide from human protein at AA range: 10-50
SpecificityThe antibody detects endogenous FSHβ
Gene NameFSHB
Protein NameFollitropin subunit beta (Follicle-stimulating hormone beta subunit) (FSH-B) (FSH-beta) (Follitropin beta chain)
Other NameFollicle Stimulating Hormone; / Follicle stimulating hormone beta polypeptide; / Follicle stimulating hormone beta subunit; / Follitropin beta chain; / Follitropin subunit beta; / FSH-B; / FSH-beta; / FSHB; / FSHbeta
SpeciesHuman
Gene ID2488
UniprotP01225,
Species.1Mouse
Gene ID.114308
Uniprot.1Q60687,
Species.2Rat
Gene ID.2
Uniprot.2P18427
Cellular LocalizationSecreted . Efficient secretion requires dimerization with CGA. .
Tissue Expression
Signaling_pathwayOrganismal Systems >> Endocrine system >> GnRH signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas>>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>GnRH signaling pathway; / >>Ovarian steroidogenesis
FunctionDisease:Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency (IFSHD) [MIM:229070]. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men.,Function:Stimulates development of follicle and spermatogenesis in the reproductive organs.,online information:Follicle-stimulating hormone entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the names Gonal-F or Metrodin HP (Serono) and Puregon (Organon). Used in the treatment of infertility in women with proven hypopituitarism or who have not responded to clomifene; or in superovulation treatment for assisted conception (such as in vitro fertilization). Metrodin HP is also used in the treatment of hypogonadotrophic hypogonadism in men for the stimulation of spermatogenesis.,similarity:Belongs to the glycoprotein hormones subunit beta family.,subunit:Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.,
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