Product details
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FUT9 rabbit pAb
Ucallm_WP8957-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | FUT9 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 39kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FUT9 |
| Specificity | This antibody detects endogenous levels of FUT9 at Human, Mouse,Rat |
| Gene Name | FUT9 |
| Protein Name | Alpha-(1,3)-fucosyltransferase (Fucosyltransferase 9) (Fucosyltransferase IX) (Fuc-TIX) (FucT-IX) (Galactoside 3-L-fucosyltransferase) |
| Other Name | |
| Species | Human |
| Gene ID | 10690 |
| Uniprot | Q9Y231, |
| Species.1 | Mouse |
| Gene ID.1 | 14348 |
| Uniprot.1 | O88819, |
| Species.2 | Rat |
| Gene ID.2 | 84597 |
| Uniprot.2 | Q99JB3 |
| Cellular Localization | Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein . Golgi apparatus membrane . |
| Tissue Expression | Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus (PubMed:10386598). Highly expressed in granulocytes. Not expressed in monocytes (PubMed:11278338). |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth . Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis . Furthermore, it is capable of synthesizing Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis . May also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. |
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