SKU: WR5120 Categories: ,

U-Blot® P2Y12 Rabbit mAb

Price range: $268.00 through $328.00

SKU: WR5120-50
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Product details

Background:The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],

Specifications

Size50μL/100μL
TargetP2Y12
ReactivityHuman, Mouse, Rat
ApplicationsWB, IF, IP, ELISA, IHC
MW(Calculated)39kD
MW(Observed)55kD
Host SpeciesRabbit
IsotypeIgG,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; IHC 1:1000-1:5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRM1329R
ImmunogenThe specific immunogen used to produce this antibody is proprietary information.
SpecificityEndogenous
Gene NameP2RY12 HORK3
Protein NameP2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999)
Other Name
SpeciesHuman
Gene ID64805
UniprotQ9H244,
Species.1Mouse
Gene ID.1
Uniprot.1Q9CPV9,
Species.2Rat
Gene ID.2
Uniprot.2Q9EPX4
Cellular LocalizationCell membrane; Multi-pass membrane protein .
Tissue ExpressionHighly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.
Signaling_pathwayOrganismal Systems >> Immune system >> Platelet activation
Research Areas>>Platelet activation
FunctionDisease:Defects in P2RY12 are a cause of bleeding disorder [MIM:609821].,Function:Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.,
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