Name: G6PC2 rabbit pAb
SKU: WP3475
Price: 268 USD
Availability: InStock

G6PC2 rabbit pAb

Ucallm_WP3475-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP3475-100

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Product details

Background:

This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	G6PC2
Reactivity	Human, Mouse
Applications	WB
MW(Calculated)
MW(Observed)	38kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human G6PC2 AA range: 175-225
Specificity	This antibody detects endogenous levels of G6PC2 at Human/Mouse
Gene Name	G6PC2 IGRP
Protein Name	G6PC2
Other Name	Glucose-6-phosphatase 2; / G-6-Pase 2; / G6Pase 2; / Islet-specific glucose-6-phosphatase catalytic subunit-related protein
Species	Human
Gene ID	57818
Uniprot	Q9NQR9,
Species.1	Mouse
Gene ID.1	14378
Uniprot.1	Q9Z186
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Endoplasmic reticulum membrane; Multi-pass membrane protein .
Tissue Expression	Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level).
Signaling_pathway	Organismal Systems >> Endocrine system >> Insulin signaling pathway;Organismal Systems >> Endocrine system >> Glucagon signaling pathway;Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Research Areas	>>Glycolysis / Gluconeogenesis; / >>Galactose metabolism; / >>Starch and sucrose metabolism; / >>Metabolic pathways; / >>FoxO signaling pathway; / >>PI3K-Akt signaling pathway; / >>AMPK signaling pathway; / >>Insulin signaling pathway; / >>Adipocytokine signaling pathway; / >>Glucagon signaling pathway; / >>Insulin resistance; / >>Carbohydrate digestion and absorption
Function	Catalytic activity:D-glucose 6-phosphate + H(2)O = D-glucose + phosphate.,Disease:Genetic variation in G6PC2 is associated with fasting plasma glucose levels quantitative trait locus type 1 (FGQTL1) [MIM:612108]. The normal fasting plasma glucose level in the plasma is defined as less than 100 mg per deciliter (5.55 mmol per liter). Higher fasting plasma glucose levels predict type 2 diabetes in young adults and increases the risk of mortality.,Function:May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis.,pathway:Carbohydrate biosynthesis; gluconeogenesis.,PTM:N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome.,similarity:Belongs to the glucose-6-phosphatase family.,tissue specificity:Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level).,