GABARAP Polyclonal Antibody
Ucallm_WP15739-50
Price range: $268.00 through $328.00
Product details
Background:
function:Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the MAP1 LC3 family., subunit:Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ULK1., tissue specificity:Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.,
Specifications
| Size | 50μL/100μL |
| Target | GABARAPL2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 17kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:10000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic Peptide of GABARAP AA range: 26-75 |
| Specificity | GABARAP Polyclonal Antibody detects endogenous levels of GABARAP |
| Gene Name | GABARAPL2 FLC3A GEF2 |
| Protein Name | GABARAP |
| Other Name | GABA; / A; / receptor-associated protein-like 2 |
| Species | Human |
| Gene ID | 11345 |
| Uniprot | P60520, |
| Species.1 | Mouse |
| Gene ID.1 | 93739 |
| Uniprot.1 | P60521, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P60522 |
| Cellular Localization | Cytoplasmic vesicle, autophagosome . Endoplasmic reticulum membrane . Golgi apparatus . |
| Tissue Expression | Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway |
| Research Areas | >>FoxO signaling pathway; / >>Autophagy - other; / >>Mitophagy - animal; / >>Autophagy - animal; / >>NOD-like receptor signaling pathway; / >>GABAergic synapse |
| Function | Function:Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MAP1 LC3 family.,subunit:Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ULK1.,tissue specificity:Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine., |
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