Name: GADD45α mouse mAb
SKU: WM0715
Price: 268 USD
Availability: InStock

Product details

Background:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010],

Specifications

Target	GADD45α
Reactivity	Transfected
Applications	WB
MW(Calculated)
MW(Observed)	22kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:1000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	14F4
Immunogen	Purified recombinant human GADD45 α protein expressed in E.coli
Sequence
Specificity	Transfected Only.
Gene Name	gadd45a
Protein Name
Other Name	DDIT 1; / DDIT-1; / DDIT1; / DNA damage inducible transcript 1; / DNA damage-inducible transcript 1 protein; / GA45A_HUMAN; / GADD45; / GADD45A; / Growth arrest and DNA damage inducible 45 alpha; / Growth arrest and DNA damage inducible alpha; / Growth arrest and DNA damage-inducible protein GADD45 alpha.
Species	Human
Gene ID-1	1647
Uniprot	P24522,
Species.1	Mouse
Gene ID-2
Uniprot.1	P48316
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010],
Cellular Localization	Nucleus .
Tissue Expression	Bronchial epithelial cells treated with 20 uM arsenic for 4
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cell cycle;Cellular Processes >> Cell growth and death >> Apoptosis;Cellular Processes >> Cell growth and death >> p53 signaling pathway;Cellular Processes >> Cell growth and death >> Cellular senescence;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Colorectal cancer;Human Diseases >> Cancer: specific types >> Pancreatic cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Glioma;Human Diseases >> Cancer: specific types >> Thyroid cancer;Human Diseases >> Cancer: specific types >> Chronic myeloid leukemia;Human Diseases >> Cancer: specific types >> Basal cell carcinoma;Human Diseases >> Cancer: specific types >> Melanoma;Human Diseases >> Cancer: specific types >> Endometrial cancer;Human Diseases >> Cancer: specific types >> Breast cancer;Human Diseases >> Cancer: specific types >> Small cell lung cancer;Human Diseases >> Cancer: specific types >> Non-small cell lung cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway
Research Areas	>>MAPK signaling pathway; / >>NF-kappa B signaling pathway; / >>FoxO signaling pathway; / >>Cell cycle; / >>p53 signaling pathway; / >>Apoptosis; / >>Cellular senescence; / >>Epstein-Barr virus infection; / >>Pathways in cancer; / >>Transcriptional misregulation in cancer; / >>Colorectal cancer; / >>Pancreatic cancer; / >>Endometrial cancer; / >>Glioma; / >>Thyroid cancer; / >>Basal cell carcinoma; / >>Melanoma; / >>Chronic myeloid leukemia; / >>Small cell lung cancer; / >>Non-small cell lung cancer; / >>Breast cancer; / >>Hepatocellular carcinoma; / >>Gastric cancer
Function	Disease:Induction of GADD45 in ataxia telangiectasia cells is abnormal.,Function:Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.,induction:By UV radiation, X-rays, growth arrest and alkylating agents. The induction is mediate by some kinase(s) other than PKC.,similarity:Belongs to the GADD45 family.,subunit:Interacts with GADD45GIP1.,
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GADD45α mouse mAb

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GADD45α mouse mAb

Product details

Specifications

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