Name: Gads Polyclonal Antibody
SKU: WP12405
Price: 268 USD
Availability: InStock

Gads Polyclonal Antibody

Ucallm_WP12405-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP12405-100

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Product details

Background:

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],

Specifications

Target	GRAP2
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	38kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human GRAP2. AA range:121-170
Sequence
Specificity	Gads Polyclonal Antibody detects endogenous levels of Gads protein.
Gene Name	GRAP2
Protein Name	GRB2-related adapter protein 2
Other Name	GRAP2; / GADS; / GRB2L; / GRID; / GRB2-related adapter protein 2; / Adapter protein GRID; / GRB-2-like protein; / GRB2L; / GRBLG; / GRBX; / Grf40 adapter protein; / Grf-40; / Growth factor receptor-binding protein; / Hematopoietic cell-associated adapter protein Grp
Species	Human
Gene ID-1	9402
Uniprot	O75791,
Species.1	Mouse
Gene ID-2
Uniprot.1	O89100
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],
Cellular Localization	Nucleus . Cytoplasm . Endosome .
Tissue Expression	Blood,Lung,Platelet,Spleen,T-cell,Thymus,
Signaling_pathway	Organismal Systems >> Immune system >> T cell receptor signaling pathway
Research Areas	>>T cell receptor signaling pathway
Function	Function:Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.,similarity:Belongs to the GRB2/sem-5/DRK family.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB.,
RRID