Name: Galectin 3 [ABT-GAL3] mouse mAb
SKU: WM1422
Price: 268 USD
Availability: InStock

Product details

Background:
Galectin-3 is a member of the β-galactose binding lectin family with a molecular weight of 30 kDa which is a chimeric structure consisting of a β-galactoside binding protein and a laminin. The main role of Galectin-3 on the cell surface is related to the adhesion between similar cells. It is expressed in a variety of organs and tissues, including neutrophils and vascular endothelial cells, but it is obviously absent in normal hepatocytes. Galectin-3 can downregulate the expression of some cancers and breast cancer associated proteins, and promote tumor metastasis. It can be used as a reference index for the degree of tumor deterioration.

Specifications

Target	Galectin-3
Reactivity	Human
Applications	IHC, WB, IF, ELISA
MW(Calculated)	26kD
MW(Observed)	33kD
Host Species	Mouse
Isotype	IgG2b,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	ABT-GAL3
Immunogen	Synthesized peptide derived from human Galectin-3 AA range: 150-250
Sequence
Specificity	The antibody can specifically recognize human Galectin-3 protein. In western blotting of Hela, A431 and MCF7 cell lysates, the antibody can label a 30 kDa band corresponding to Galectin-3, while there is no band detected in Galectin-3 knock out Hela cell lysate.
Gene Name	LGALS3 MAC2
Protein Name	Galectin 3
Other Name	90K; / 90K MAC 2 BP; / Basement membrane autoantigen p105; / BTBD17B; / Galectin 3 binding protein; / Galectin-3-binding protein; / L3 antigen; / Lectin galactoside binding soluble 3 binding protein; / Lectin galactoside-binding soluble 3-binding protein; / LG3BP_HUMAN; / LGALS3BP; / M2BP; / Mac 2 binding protein; / Mac 2 BP; / Mac-2 BP; / Mac-2-binding protein; / Mac2 BP; / MAC2BP; / Serum protein 90K; / TANGO10B; / Transport and golgi organization 10 homolog B; / Tumor associated antigen 90K; / Tumor-associated antigen 90K
Species	Human
Gene ID-1	3958
Uniprot	P17931
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	Galectin-3 is a member of the β-galactose binding lectin family with a molecular weight of 30 kDa which is a chimeric structure consisting of a β-galactoside binding protein and a laminin. The main role of Galectin-3 on the cell surface is related to the adhesion between similar cells. It is expressed in a variety of organs and tissues, including neutrophils and vascular endothelial cells, but it is obviously absent in normal hepatocytes. Galectin-3 can downregulate the expression of some cancers and breast cancer associated proteins, and promote tumor metastasis. It can be used as a reference index for the degree of tumor deterioration.
Cellular Localization	Cytoplasmic, Nuclear
Tissue Expression	A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.
Signaling_pathway
Research Areas
Function	Function:Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis.,online information:Galectin-3,similarity:Contains 1 galectin domain.,subcellular location:Cytoplasmic in adenomas and carcinomas. May be secreted by a non-classical secretory pathway and associate with the cell surface.,subunit:Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.,tissue specificity:A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages.,
RRID

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Galectin 3 [ABT-GAL3] mouse mAb

Product details

Specifications

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Galectin 3 [ABT-GAL3] mouse mAb

Product details

Specifications

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