Name: Galectin-9 [PTR1201] mouse mAb
SKU: WM1353
Price: 268 USD
Availability: InStock

Product details

Background:
galectin 9(LGALS9) Homo sapiens The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Galectin-9
Reactivity	Human
Applications	WB, IF, ELISA
MW(Calculated)	39kD
MW(Observed)	37kD
Host Species	Mouse
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Monoclonal
Clone Number	RMMR1201
Immunogen	Synthesized peptide derived from human Galectin-9 AA range: 1-100
Specificity	This antibody detects endogenous levels of Galectin-9 protein.
Gene Name	LGALS9
Protein Name	Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)
Other Name
Species	Human
Gene ID	3965
Uniprot	O00182,
Species.1	Mouse
Gene ID.1	16859
Uniprot.1	O08573
Species.2
Gene ID.2
Uniprot.2
Cellular Localization
Tissue Expression	Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells in decidua and placenta in pregnancy (at protein level) (PubMed:23242525, PubMed:25578313). Isoform 2 is the most abundant isoform expressed in endothelial cells (PubMed:24333696). Upon endothelial cell activation isoform 2 expression decreases while expression of isoform 3 and isoform 5 increases (PubMed:24333696). Isoform 4 decreases in pathological pregnancy (PubMed:23242525).
Signaling_pathway
Research Areas
Function	Binds galactosides . Has high affinity for the Forssman pentasaccharide . Ligand for HAVCR2/TIM3 . Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death . Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration . Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation . Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection . Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells . Inhibits degranulation and induces apoptosis of mast cells . Induces maturation and migration of dendritic cells . Inhibits natural killer (NK) cell function . Can transform NK cell phenotype from peripheral to decidual during pregnancy . Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity).; [Isoform 2]: Acts as an eosinophil chemoattractant . It also inhibits angiogenesis . Suppresses IFNG production by natural killer cells (By similarity).

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Galectin-9 [PTR1201] mouse mAb

Product details

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Galectin-9 [PTR1201] mouse mAb

Product details

Specifications

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