Product details
Background:
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GCOM1 rabbit pAb
Ucallm_WP7889-50
Price range: $268.00 through $328.00
Specifications
| Target | MYZAP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 51kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GCOM1 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of GCOM1 at Human, Mouse,Rat |
| Gene Name | MYZAP MYOZAP |
| Protein Name | Myocardial zonula adherens protein (GRINL1A upstream protein) (Gup) |
| Other Name | |
| Species | Human |
| Gene ID-1 | 100820829 |
| Uniprot | P0CAP1, |
| Species.1 | Mouse |
| Gene ID-2 | 102371 |
| Uniprot.1 | Q3UIJ9, |
| Species.2 | Rat |
| Gene ID-3 | 363091 |
| Uniprot.2 | Q5EB94 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Cytoplasm, cytoskeleton . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasm, myofibril, sarcomere, I band . Cytoplasm, myofibril, sarcomere, Z line . Cell junction . Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin. . |
| Tissue Expression | Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis. Expressed in arrector pili muscle (at protein level) (PubMed:29034528). |
| Signaling_pathway | |
| Research Areas | |
| Function | Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). |
| RRID |
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