Need Help? +(1)-866-986-9598
0 My Cart$0.00
Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/Glial Fibrillary Acidic Protein [GFAP] [ABT176] mouse mAb
SKU: WM1424 Categories: ,

Glial Fibrillary Acidic Protein [GFAP] [ABT176] mouse mAb

Ucallm_WM1424-50

Price range: $268.00 through $328.00

SKU: WM1424-50
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:
GFAP is an intermediate filament protein with a molecular weight of 51 kDa, which participates in the formation of cytoskeleton and maintains its tension strength. GFAP is mainly distributed in astrocytes and ependymal cells of the central nervous system, Schwann cells and satellite cells of intestinal ganglion of the peripheral nervous system, myoepithelial cells and chondroblasts. It is mainly used for the diagnosis and differential diagnosis of astrocytoma, including astrocytoma, astroblastoma, mixed glioma, pleomorphic glioblastoma and non astrocytoma, including a few gliomas, most ependymomas and other central nervous system tumors.

Specifications

Size50μL/100μL
TargetGlial Fibrillary Acidic Protein
ReactivityHuman, Rat, Monkey, Bovine
ApplicationsIHC, WB, IF, ELISA
MW(Calculated)49kD
MW(Observed)50kD
Host SpeciesMouse
IsotypeIgG2b,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMM176
ImmunogenSynthesized peptide derived from human Glial Fibrillary Acidic Protein AA range: 300-432
SpecificityThe antibody can specifically recognize human GFAP protein.
Gene NameGFAP
Protein Namewu:fb34h11; ALXDRD; cb345; etID36982.3; FLJ42474; FLJ45472; GFAP; GFAP_HUMAN; gfapl; Glial fibrillary acidic protein; Intermediate filament protein; wu:fk42c12; xx:af506734; zgc:110485
Other Namewu:fb34h11; / ALXDRD; / cb345; / etID36982.3; / FLJ42474; / FLJ45472; / GFAP; / GFAP_HUMAN; / gfapl; / Glial fibrillary acidic protein; / Intermediate filament protein; / wu:fk42c12; / xx:af506734; / zgc:110485
SpeciesHuman
Gene ID2670
UniprotP14136,
Species.1Mouse
Gene ID.1
Uniprot.1P03995,
Species.2Rat
Gene ID.2
Uniprot.2P47819
Cellular LocalizationCytoplasmic
Tissue ExpressionBrain/ Colon
Signaling_pathwayEnvironmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Research Areas>>JAK-STAT signaling pathway
FunctionAlternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons,Disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.,Function:GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.,online information:GFAP entry,similarity:Belongs to the intermediate filament family.,subcellular location:Associated with intermediate filaments.,subunit:Interacts with SYNM (By similarity). Isoform 3 interacts with PSEN1 (via N-terminus).,tissue specificity:Expressed in cells lacking fibronectin.,
Please login to post questions

Related products

J774A.1 cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with primary antibody 1:1000. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.
Sku: WR4006
Categories: ,

U-Blot® NLRP3 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: W2213
Categories: ,

U-Blot™ SSPE buffer, pH 7.4

0 Reviews
$199.00
Add to cartBulk Quote
Western blot analysis of lysates from K562 cells, using α smooth muscle actin Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
Sku: WR4021
Categories: ,

U-Blot® α smooth muscle actin Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WR4012
Categories: ,

U-Blot® CDC37 (Phospho Ser13) Rabbit mAb

0 Reviews
Price range: $288.00 through $368.00
Select options
Sku: WR4003
Categories: ,

U-Blot® PMS2 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WR4019
Categories: ,

U-Blot® Cyclin B1 (Phospho Ser126) Rabbit mAb

0 Reviews
Price range: $288.00 through $368.00
Select options

Customer Reviews

  • Shop Categories
Menu
Need Help? +(1)-866-986-9598
Back to Top
Product has been added to your cart