SKU: WM1672 Categories: ,

Glycophorin A [ABT-GYPA] mouse mAb

Price range: $268.00 through $328.00

SKU: WM1672-50
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Product details

Background:
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetGlycophorin A
ReactivityHuman
ApplicationsIHC, ELISA
MW(Calculated)16kD
MW(Observed)37kD
Host SpeciesMouse
IsotypeIgG1,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-400; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationThe antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMM-GYPA
ImmunogenSynthesized peptide derived from human Glycophorin A,CD235a AA range: 1-100
SpecificityThe antibody can specifically recognize human Glycophorin A protein.
Gene NameGYPA GPA
Protein NameGlycophorin A,CD235a
Other NameGlycophorin-A; / MN sialoglycoprotein; / PAS-2; / Sialoglycoprotein alpha; / CD antigen CD235a
SpeciesHuman
Gene ID2993
UniprotP02724
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembranous
Tissue ExpressionBlood,Bone marrow,Kidney,Liver,Lung,Miltenberger class V,
Signaling_pathwayOrganismal Systems >> Immune system >> Hematopoietic cell lineage
Research Areas>>Hematopoietic cell lineage; / >>Malaria
FunctionFunction:Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors and also binds influenza virus.,online information:Blood group antigen gene mutation database,polymorphism:Along with GYPB, GYPA is responsible for the MNS blood group system.,similarity:Belongs to the glycophorin A family.,
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