Glycophorin A [ABT-GYPA] mouse mAb
Ucallm_WM1425-50
Price range: $268.00 through $328.00
Product details
Background:
Glycophorin A, also known as CD235a, is a sialic acid glycoprotein located on the surface of human erythrocytes. It is a erythroid specific antigen. Its expression is accompanied by the whole process of erythropoiesis. Maintaining high expression on erythrocytes indicates that the erythrocytes are mature. Oncogenic nucleated erythrocytes in most erythroid derived leukemia express this protein, while acute myeloid leukemia and acute lymphoma leukemia almost do not express, which is a useful marker to identify erythroid differentiation in hematopoietic malignancies.
Specifications
| Size | 50μL/100μL |
| Target | Glycophorin A |
| Reactivity | Human |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 16kD |
| MW(Observed) | 37kD |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM-GYPA |
| Immunogen | Synthesized peptide derived from human Glycophorin A，CD235a AA range: 1-100 |
| Specificity | The antibody can specifically recognize human Glycophorin A protein. |
| Gene Name | GYPA GPA |
| Protein Name | Glycophorin A，CD235a |
| Other Name | AI853584; / Blood group--MN locus; / CD_antigen=CD235a; / CD235a; / GLPA_HUMAN; / Glycophorin A; / MNS blood group; / Glycophorin A; / Glycophorin A, included; / Glycophorin-A; / GlycophorinA; / GPA; / GPErik; / GpMiIII; / GPSAT; / GYPA; / GYPA, included; / HGpMiIII; / HGpMiV; / HGpMiX; / HGpMiXI; / HGpSta; / C; / MN; / MN sialoglycoprotein; / MNS; / PAS-2; / PAS2; / Sialoglycoprotein alpha |
| Species | Human |
| Gene ID | 2993 |
| Uniprot | P02724 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membranous |
| Tissue Expression | Blood,Bone marrow,Kidney,Liver,Lung,Miltenberger class V, |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage |
| Research Areas | >>Hematopoietic cell lineage; / >>Malaria |
| Function | Function:Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors and also binds influenza virus.,online information:Blood group antigen gene mutation database,polymorphism:Along with GYPB, GYPA is responsible for the MNS blood group system.,similarity:Belongs to the glycophorin A family., |
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