Name: HAND1 Monoclonal Antibody
SKU: WM0230
Price: 268 USD
Availability: InStock

HAND1 Monoclonal Antibody

Ucallm_WM0230-50

Price range: $268.00 through $328.00

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SKU: WM0230-50

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Product details

Background:
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	HAND1
Reactivity	Human
Applications	WB, ELISA
MW(Calculated)	24kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	6C6
Immunogen	Purified recombinant fragment of HAND1 (aa90-190) expressed in E. Coli.
Specificity	HAND1 Monoclonal Antibody detects endogenous levels of HAND1 protein.
Gene Name	HAND1
Protein Name	Heart- and neural crest derivatives-expressed protein 1
Other Name	HAND1; / BHLHA27; / EHAND; / Heart- and neural crest derivatives-expressed protein 1; / Class A basic helix-loop-helix protein 27; / bHLHa27; / Extraembryonic tissues; / heart, autonomic nervous system and neural crest derivatives-expressed protein 1; / eH
Species	Human
Gene ID	9421
Uniprot	O96004,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q64279
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus, nucleoplasm . Nucleus, nucleolus . Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). .
Tissue Expression	Heart.
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells
Research Areas	>>Signaling pathways regulating pluripotency of stem cells
Function	Function:Plays an essential role in early trophoblast differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box).,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors).,tissue specificity:Heart.,

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HAND1 Monoclonal Antibody

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HAND1 Monoclonal Antibody

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