SKU: WP12719 Categories: ,

hnRNP G Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12719-100
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Product details

Background:

This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns. [provided by RefSeq, Sep 2009],

Specifications

Size50μL/100μL
TargethnRNP G
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)40kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human hnRNP G. AA range:6-55
SpecificityhnRNP G Polyclonal Antibody detects endogenous levels of hnRNP G protein.
Gene NameRBMX
Protein NameRNA-binding motif protein X chromosome
Other NameRBMX; / HNRPG; / RBMXP1; / RNA-binding motif protein; / X chromosome; / Glycoprotein p43; / Heterogeneous nuclear ribonucleoprotein G; / hnRNP G
SpeciesHuman
Gene ID27316
UniprotP38159,
Species.1Mouse
Gene ID.119655
Uniprot.1Q9WV02,
Species.2Rat
Gene ID.2302855
Uniprot.2Q4V898
Cellular LocalizationNucleus . Component of ribonucleosomes. Localizes in numerous small granules in the nucleus.
Tissue ExpressionExpressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level).
Signaling_pathway
Research Areas>>Spliceosome
FunctionFunction:RNA-binding protein which may be involved in pre-mRNA splicing.,PTM:Arg-185 is dimethylated, probably to asymmetric dimethylarginine.,PTM:Cleavage of initiator Met is partial. If Met-1 is not removed, it is acetylated. If it is removed, Val-2 is acetylated.,PTM:O-glycosylated.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Component of ribonucleosomes.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Interacts with KHDRBS3.,
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