Price range: $268.00 through $328.00
Background:
This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | HSP70L |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 70kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HSPA1L. AA range:221-270 |
| Specificity | HSP70 Polyclonal Antibody detects endogenous levels of HSP70 protein. |
| Gene Name | HSPA1L/HSPA1A |
| Protein Name | Heat shock 70 kDa protein 1-like/Heat shock 70 kDa protein 1A/1B |
| Other Name | HSPA1L; / Heat shock 70 kDa protein 1-like; / Heat shock 70 kDa protein 1L; / Heat shock 70 kDa protein 1-Hom; / HSP70-Hom; / HSPA1A; / HSPA1; / HSPA1B; / Heat shock 70 kDa protein 1A/1B; / Heat shock 70 kDa protein 1/2; / HSP70-1/HSP70-2; / HSP70.1/HSP70.2 |
| Species | Human |
| Gene ID | 3305;3303;3304 |
| Uniprot | P34931;P08107, |
| Species.1 | Mouse |
| Gene ID.1 | 15482;193740, |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 24963;24472 |
| Uniprot.2 | P55063;Q07439 |
| Cellular Localization | zona pellucida receptor complex,nucleoplasm,mitochondrial matrix,cytosol,COP9 signalosome,cell body,blood microparticle, |
| Tissue Expression | Expressed in spermatids. |
| Signaling_pathway | Organismal Systems >> Immune system >> Antigen processing and presentation;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species;Human Diseases >> Neurodegenerative disease >> Prion disease;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum |
| Research Areas | >>Spliceosome; / >>MAPK signaling pathway; / >>Protein processing in endoplasmic reticulum; / >>Endocytosis; / >>Longevity regulating pathway - multiple species; / >>Antigen processing and presentation; / >>Estrogen signaling pathway; / >>Prion disease; / >>Legionellosis; / >>Toxoplasmosis; / >>Measles; / >>Lipid and atherosclerosis |
| Function | Function:In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.,induction:Not induced by heat shock.,similarity:Belongs to the heat shock protein 70 family.,tissue specificity:Expressed in spermatids., |
