SKU: WP15205 Categories: ,

HSP77/76 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15205-100
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Product details

Background:

caution:Could be the product of a pseudogene., function:In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage., induction:Only at higher temperatures, and no basal expression., similarity:Belongs to the heat shock protein 70 family.,

Specifications

Size50μL/100μL
TargetHSP77/76
ReactivityHuman
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)40kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from the Internal region of human HSP77/76.
SpecificityHSP77/76 Polyclonal Antibody detects endogenous levels of HSP77/76 protein.
Gene NameHSPA6/HSPA7
Protein NameHeat shock 70 kDa protein 6/Putative heat shock 70 kDa protein 7
Other NameHSPA7; / HSP70B; / Putative heat shock 70 kDa protein 7; / Heat shock 70 kDa protein B; / HSPA6; / HSP70B'; / Heat shock 70 kDa protein 6; / Heat shock 70 kDa protein B'
SpeciesHuman
Gene ID3310
UniprotP48741
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCOP9 signalosome,extracellular exosome,blood microparticle,
Tissue ExpressionCerebellum,Lung,Ovary,Skin,
Signaling_pathwayOrganismal Systems >> Immune system >> Antigen processing and presentation;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species;Human Diseases >> Neurodegenerative disease >> Prion disease;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum
Research Areas
FunctionCaution:Could be the product of a pseudogene.,Function:In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.,induction:Only at higher temperatures, and no basal expression.,similarity:Belongs to the heat shock protein 70 family.,
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