Price range: $268.00 through $328.00
Background:
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014],
| Size | 50μL/100μL |
| Target | I5P2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 109kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human I5P2 AA range: 292-342 |
| Specificity | This antibody detects endogenous levels of I5P2 at Human/Mouse |
| Gene Name | INPP5B OCRL2 |
| Protein Name | I5P2 |
| Other Name | |
| Species | Human |
| Gene ID | 3633 |
| Uniprot | P32019, |
| Species.1 | Mouse |
| Gene ID.1 | 16330 |
| Uniprot.1 | Q8K337 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytosol . Endoplasmic reticulum-Golgi intermediate compartment . Early endosome membrane . Membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle, phagosome membrane . Golgi apparatus . |
| Tissue Expression | Platelets. |
| Signaling_pathway | |
| Research Areas | >>Inositol phosphate metabolism; / >>Metabolic pathways; / >>Phosphatidylinositol signaling system |
| Function | Catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.,Function:Hydrolyzes the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.,similarity:Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Platelets., |
