IBTK Polyclonal Antibody
Ucallm_WP0581-50
Price range: $268.00 through $328.00
Product details
Background:
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],
Specifications
| Size | 50μL/100μL |
| Target | IBTK |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 148kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 410-490 |
| Specificity | IBTK Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | IBTK BTKI KIAA1417 |
| Protein Name | Inhibitor of Bruton tyrosine kinase (IBtk) |
| Other Name | |
| Species | Human |
| Gene ID | 25998 |
| Uniprot | Q9P2D0, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q6ZPR6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Membrane; Peripheral membrane protein. Translocates to the plasma membrane upon IgM stimulation.; [Isoform 2]: Nucleus. |
| Tissue Expression | Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.,similarity:Contains 2 BTB (POZ) domains.,similarity:Contains 3 ANK repeats.,similarity:Contains 3 RCC1 repeats.,subcellular location:Translocates to the plasma membrane upon IgM stimulation.,subunit:Interacts with the PH domain of BTK.,tissue specificity:Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues., |
Please login to post questions
Related products
