IL-8 Polyclonal Antibody
Ucallm_WP12829-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | IL-8 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 8kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IL-8. AA range:19-68 |
| Specificity | IL-8 Polyclonal Antibody detects endogenous levels of IL-8 protein. |
| Gene Name | IL8 CXCL8 |
| Protein Name | Interleukin-8 |
| Other Name | IL8; / CXCL8; / Interleukin-8; / IL-8; / C-X-C motif chemokine 8; / Emoctakin; / Granulocyte chemotactic protein 1; / GCP-1; / Monocyte-derived neutrophil chemotactic factor; / MDNCF; / Monocyte-derived neutrophil-activating peptide; / MONAP; / Neutrophil-activati |
| Species | Human |
| Gene ID | 3576 |
| Uniprot | P10145 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Chronic myeloid leukemia cell,Kidney,Lung,Lung carcinoma,Neutrophil,Periphe |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Cellular senescence;Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway;Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Immune system >> Chemokine signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Bladder cancer;Human Diseases >> Immune disease >> Rheumatoid arthritis;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway; / >>NF-kappa B signaling pathway; / >>Phospholipase D signaling pathway; / >>Cellular senescence; / >>Toll-like receptor signaling pathway; / >>NOD-like receptor signaling pathway; / >>RIG-I-like receptor signaling pathway; / >>IL-17 signaling pathway; / >>Non-alcoholic fatty liver disease; / >>AGE-RAGE signaling pathway in diabetic complications; / >>Alcoholic liver disease; / >>Epithelial cell signaling in Helicobacter pylori infection; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Salmonella infection; / >>Pertussis; / >>Legionellosis; / >>Yersinia infection; / >>Chagas disease; / >>Malaria; / >>Amoebiasis; / >>Hepatitis B; / >>Human cytomegalovirus infection; / >>Influenza A; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Coronavirus disease - COVID-19; / >>Pathways in cancer; / >>Transcriptional misregulation in cancer; / >>Bladder cancer; / >>Rheumatoid arthritis; / >>Lipid and atherosclerosis |
| Function | Function:IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.,online information:Interleukin-8 entry,PTM:Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,subunit:Homodimer., |
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