Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011],
| Target | IL18 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 21kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000; IF 1:100-300; ELISA 1:5000-20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Sequence | |
| Specificity | IL18 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | IL18 IGIF IL1F4 |
| Protein Name | Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) |
| Other Name | |
| Species | Human |
| Gene ID-1 | 3606 |
| Uniprot | Q14116, |
| Species.1 | Mouse |
| Gene ID-2 | |
| Uniprot.1 | P70380, |
| Species.2 | Rat |
| Gene ID-3 | |
| Uniprot.2 | P97636 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011], |
| Cellular Localization | Cytoplasm . Secreted . The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). . |
| Tissue Expression | Liver,Peripheral blood,Urinary bladder, |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway;Human Diseases >> Immune disease >> Rheumatoid arthritis;Human Diseases >> Immune disease >> Inflammatory bowel disease;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>NOD-like receptor signaling pathway; / >>Cytosolic DNA-sensing pathway; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Salmonella infection; / >>Legionellosis; / >>Yersinia infection; / >>African trypanosomiasis; / >>Malaria; / >>Tuberculosis; / >>Influenza A; / >>Inflammatory bowel disease; / >>Rheumatoid arthritis; / >>Lipid and atherosclerosis |
| Function | Function:Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.,online information:Interleukin-1 entry,similarity:Belongs to the IL-1 family., |
| RRID | AB_2921216 |
