This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008],
Specifications
Size
50μL/100μL
Target
IMP3
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, ELISA
MW(Calculated)
MW(Observed)
25kD
Host Species
Rabbit
Isotype
IgG
Conjugate/Modification
Unmodified
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:500-2000; ELISA 1:10000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthetic peptide from human protein at AA range: 135-184
Specificity
The antibody detects endogenous Imp3 protein
Gene Name
IMP3 C15orf12 MRPS4
Protein Name
U3 small nucleolar ribonucleoprotein protein IMP3
Other Name
IMP 3; / IMP-3; / U3 small nucleolar ribonucleoprotein protein IMP3; / C15orf12; / MRPS4; / U3 snoRNP protein IMP3; / BRMS2
Species
Human
Gene ID
55272
Uniprot
Q9NV31,
Species.1
Mouse
Gene ID.1
102462
Uniprot.1
Q921Y2
Species.2
Gene ID.2
Uniprot.2
Cellular Localization
Nucleus, nucleolus .
Tissue Expression
Eye,Placenta,Uterus,
Signaling_pathway
Research Areas
>>Ribosome biogenesis in eukaryotes
Function
Function:Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.,similarity:Belongs to the ribosomal protein S4P family.,similarity:Contains 1 S4 RNA-binding domain.,subunit:Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.,