Product details
Background:
- Please choose product options by visiting Rabbit anti Human IgG+IgM+IgA - Cy5.5.
LEMD2 rabbit pAb
Ucallm_WP7957-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | LEMD2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 55kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human LEMD2 |
| Specificity | This antibody detects endogenous levels of LEMD2 at Human, Mouse |
| Gene Name | LEMD2 |
| Protein Name | LEM domain-containing protein 2 (hLEM2) |
| Other Name | |
| Species | Human |
| Gene ID | 221496 |
| Uniprot | Q8NC56, |
| Species.1 | Mouse |
| Gene ID.1 | 224640 |
| Uniprot.1 | Q6DVA0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus inner membrane; Multi-pass membrane protein . Nucleus envelope . Cytoplasm, cytoskeleton, spindle . Lamina-associated protein residing in the inner nuclear membrane (INM) of the nuclear envelope (NE) (PubMed:16339967). The localization to the INM is dependent on LMNA (PubMed:16339967). Evenly distributed around the NE during interphase (PubMed:16339967). During metaphase, found in a reticular network (PubMed:28242692). Recruited to the reforming NE on chromatin disks in early anaphase (PubMed:28242692). In late anaphase, concentrates at the NE core proximal to spindle microtubules, and then broadening to a distributed nuclear rim pattern (PubMed:28242692, PubMed:32494070). . |
| Tissue Expression | Ubiquitously expressed, including bone marrow, brain, kidney, colon, skeletal muscle, thymus, testis and uterus. |
| Signaling_pathway | |
| Research Areas | |
| Function | Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope integrity and nuclear envelope reformation after mitosis . Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated nuclear envelope reformation . Promotes ESCRT-mediated nuclear envelope closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase . During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing . Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). |
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