Product details
Background:
INPP5K rabbit pAb
Ucallm_WP7507-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | INPP5K |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 49kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human INPP5K |
| Specificity | This antibody detects endogenous levels of INPP5K at Human, Mouse |
| Gene Name | INPP5K PPS SKIP |
| Protein Name | Inositol polyphosphate 5-phosphatase K (Skeletal muscle and kidney-enriched inositol phosphatase) |
| Other Name | |
| Species | Human |
| Gene ID | 51763 |
| Uniprot | Q9BT40, |
| Species.1 | Mouse |
| Gene ID.1 | 19062 |
| Uniprot.1 | Q8C5L6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum . Cytoplasm . Following stimulation with EGF, translocates to membrane ruffles (PubMed:12536145, PubMed:26940976). Concentrated at the periphery of the nucleus (PubMed:10753883). . |
| Tissue Expression | Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate . Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate . Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity). |
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